Immediately bioavailable folate—bypass MTHFR conversion issues.
Quatrefolic® (6S-5-methyltetrahydrofolate) is the 4th-generation active folate form. One capsule daily delivers 600µg already in the form your body uses—no enzymatic conversion required. This matters for those with MTHFR variants or anyone wanting maximum biological activity from their folate supplement.
Why This Formula
✔ 5-MTHF (Quatrefolic®)—active form, ready to work on homocysteine and methylation
✔ 100x more water-soluble than older calcium salt derivatives
✔ Bypasses MTHFR enzyme entirely—no conversion losses
✔ Does not mask B12 deficiency unlike synthetic folic acid
✔ Preferred by clinicians for preconception, pregnancy, and postmenopausal healthWho It's For
Women planning pregnancy, those with MTHFR gene variants, anyone seeking activated folate, and postmenopausal women supporting homocysteine balance and bone health.
The xSpan Labs Standard
Small-batch manufactured in the UK to GMP and ISO 9001 standards. No unnecessary fillers, no artificial colours, no inflated marketing—just premium-grade ingredients in their most effective forms. Every batch is tested for purity and potency.
Methyl Folate 600µg - 90 Capsules as Quatrefolic 5-MTHF Supplement
Directions
Adults, take 1 capsules per day with water. Do not exceed recommended dose
Ingredients
One capsule typically provides: Maltodextrin, Capsule Shell: Hydroxypropyl Methylcellulose, Glucosamine Salt of (6S)-5-Methyltetrahydrofolate: (Folic Acid as 600µg 5-Methyltetrahydrofolic Acid, 377µg Glucosamine) as Quatrefolic®.
Cautions
Always consult your health practitioner before taking nutritional supplements, especially if you are taking medication or are under medical supervision. You should not take supplements as a substitute for a varied balanced diet or healthy lifestyle. Store in a cool, dry & dark place, under 25 degrees, out of reach of children. Allergy advice: although rigorous precautions are taken to prevent any cross-contamination, this product is manufactured in a facility that handles allergy-based materials.
Suitable for both Vegetarians or Vegans.
Methyl Folate 600µg - 90 Capsules as Quatrefolic 5-MTHF Supplement 6S-5-methyltetrahydrofolate – the 4th generation of Folate a highly biologically active form of Folic Acid:
- Supplementation with 5-methyltetrahydrofolate is preferable to one with folic acid, as it’s immediately bioavailable to react with homocysteine
- Quatrefolic® sustains healthy cell, tissue growth, digestive, and immune systems. It can improve energy production and the formation of red blood cells while promoting normal brain development and function
- Quatrefolic® as a source of (6S)-5-methyltetrahydrofolate might be particularly useful to provide the nutritionally active form of folate during preconceptions, pregnancy and lactation
- Quatrefolic® supplementation may help postmenopausal women to normalize homocysteine, contributing to helping hot flashes, cardiovascular and bone health of aging women
- Quatrefolic® is unlikely to mask vitamin B12 resulting in tangible advantages and safer profile of the product as compared with folic acid
xSpan Labs Guarantees our High-Quality products are Manufactured exclusively in the UK to GMP code of practice and ISO 9001, using only the finest quality raw materials in their highest grade and purest form so you receive a consistently high-quality product.